Thomas Lectka、19xx年xx月x日(生于底特律)-、美国的有机化学家。约翰霍普金斯大学 教授。(照片: JHU Department of Chemistry)

经历

1986 Oberlin College毕业
1991 康奈尔大学 博士学位
1992-1994 哈佛大学 博士后研究员
1994 约翰霍普金斯大学 助教
2002 约翰霍普金斯大学 教授
2012 约翰霍普金斯大学 Jean and Norman Scowe Professor of Chemistry

获奖

John Simon Guggenheim Memorial Fellow
Alfred P. Sloan Fellow
Merck Faculty Development Award
Camille Dreyfus Teacher Scholar
DuPont ATE Grant
American Cancer Society New Faculty Grantee
NSF Career Award
Eli Lilly Young Faculty Grantee
NIH First Award

研究概要

有机催化剂催化的Staudinger环化[1-4]

开发了一种有机催化剂体系，通过促进烯酰氯（一种烯酮前体）与亚胺之间的不对称[2 + 2]环加成反应合成β – 内酰胺。

溶液中氟离子生成的研究[5]

Lectka等人巧妙地设计了氟原子可以发生与相邻基团的相互作用的实验，证明了这种氟离子的干预的假设。

各种C-H氟化反应的开发[6-8]

开发出了通过铜催化或者光照条件对sp³C-H进行氟化反应的开发。

关联论文

1. (a) Taggi, A. E.; Hafez, A. M.; Wack, H.; Young, B.; Drury, W. J., III; Lectka, T. “Catalytic, Asymmetric Synthesis of beta-Lactams” J. Am. Chem. Soc. 2000, 122, 7831. DOI: 10.1021/ja001754g (b) Taggi, A. E.; Hafez, A. M.; Wack, H.; Young, B.; Ferraris, D.; Lectka, T. “The Development of the First Catalyzed Reaction of Ketenes and Imines: Catalytic, Asymmetric Synthesis of beta-Lactams” J. Am. Chem. Soc.2002, 124, 6626. DOI: 10.1021/ja0258226
2. “Nucleophilic Chiral Amines as Catalysts in Asymmetric Synthesis” France, S.; Guerin, D. J.; Miller, S. J.; Lectka, T. Chem. Rev. 2003, 103, 2985. DOI: 10.1021/cr020061a
3. “Chemical Synthesis of β- Lactams: Asymmetric Catalysis and Other Recent Advances” Pitts, C. R.; Lectka, T. Chem. Rev. 2014, 114, 7930. DOI: 10.1021/cr4005549
4. “Bifunctional Asymmetric Catalysis: Cooperative Lewis Acid/Base Systems” Paull, D. H.; Abraham, C. J.; Scerba, M. T.; Alden-Danforth, E.; Lectka, T. Acc. Chem. Res.2008, 41, 655. DOI: 10.1021/ar700261a
5. (a) “Evidence for a Symmetrical Fluoronium Ion in Solution” Struble, M. D.; Scerba, M. T.; Siegler, M.; Lectka, T. Science 2013, 340, 57. DOI: 10.1126/science.1231247 (b) “Search for a Symmetrical C-F-C Fluoronium Ion in Solution: Kinetic Isotope Effects, Synthetic Labeling, and Computational, Solvent, and Rate Studies” Struble, M. D.; Holl, M. G.; Scerba, M. T.; Siegler, M. A.; Lectka, T.  J. Am. Chem. Soc. 2015, 137, 11476. DOI: 10.1021/jacs.5b07066
6. “Direct, Catalytic Monofluorination of sp³ C-H Bonds: A Radical-Based Mechanism with Ionic Selectivity” Pitts, C. R.; Bloom, S.; Woltornist, R.; Auvenshine, D. J.; Ryzhkov, L. R.; Siegler, M. A.; Lectka, T. J. Am. Chem. Soc. 2014, 136, 9780. DOI: 10.1021/ja505136j
7. “Multiple Enone-Directed Reactivity Modes Lead to the Selective Photochemical Fluorination of Polycyclic Terpenoid Derivatives” Pitts, C. R.; Bume, D. D.; Harry, S. A.; Siegler, M. A.; Lectka, T. J. Am. Chem. Soc. 2017, 139, 2208. DOI: 10.1021/jacs.7b00335
8. “Ketones as directing groups in photocatalytic sp³ C-H fluorination” Bume, D. D.; Pitts, C. R.; Ghorbani, F.; Harry, S. A.; Capilato, J. N.; Siegler, M. A.; Lectka, T.  Chem. Sci. 2017, 8, 6918. doi:10.1039/C7SC02703F

关联链接

• T. Lectka Group

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