世界著名化学家

Timothy R. Newhouse

本文作者 alberto-caeiro

Timothy R. Newhouse,美国有机化学家,现为耶鲁大学化学系副教授,主要从事于计算化学辅助的天然产物全合成和合成方法学的研究。图片:实验室介绍

经历

  • 2001-2005, B. A., Colby College, Waterville, Advisor: Dasan M. Thamattoor
  • 2006-2010, Ph. D., The Scripps Research Institute, La Jolla, Advisor:Phil S. Baran
  • 2010-2013, Postdoctoral Research Fellow, Harvard University, Cambridge, Advisor: Elias. J. Corey
  • 2013-2018, Assistant Professor of Chemistry, Yale University, New Haven
  • 2018-present, Associate Professor of Chemistry, Yale University, New Haven

获奖经历

  • 2018 Amgen Young Investigator Award
  • 2018 Dylan Hixon’ 88 Prize for Teaching Excellence
  • 2017 ACS Academic Young Investigator
  • 2017 Sloan Research Fellowship
  • 2017 NSF CAREER
  • 2015 Rosenkranz Award
  • 2015 Thieme Chemistry Journal Award
  • 2014 Anderson Award
  • 2010-13 Bristol Myers Squibb Postdoctoral Fellowship
  • 2012 Harvard Postdoctoral Award for Professional Development
  • 2011 Reaxys PhD Prize Finalist
  • 2008 Bristol Myers Squibb Graduate Fellowship
  • 2008 Scripps Best Talk Award, Graduate Retreat, Chemistry
  • 2005 The “Sarge” Award in Chemistry for departmental leadership
  • 2005 Phi Beta Kappa Society member
  • 2004 Wayne L. Smith Inorganic Chemistry Award
  • 2003 Bradford P. Mundy Organic Chemistry Award
  • 2003 Merck/AAAS Undergraduate Research Scholar

工作介绍

1.天然产物全合成

尽管现在的有机化学已经发展出许多强大而高效的成键反应,但在具有多手性中心的复杂环骨架天然产物的全合成中,仍需要新的理念和方法用于他们的构建中。Newhouse教授尝试将计算化学和天然产物的合成结合起来,将其用于路线设计,指导后续的合成反应[1]。如2019年的JACS中,Newhouse教授利用此方法合成了Paspaline A和Emindole PB,Chem-Stat也有报道[2]

Newhouse教授聚焦于具有优异神经活性的天然产物骨架,期望此类化学小分子探针能够用于神经功能的基础研究,从而解决神经功能障碍。以下为其独立以来合成的分子。

2.羰基化合物α,β-脱氢反应

传统的烯丙基取代反应中,烯丙基钯物种被烯醇负离子进攻后发生还原消除得到偶联产物,而在Newhouse教授设计的脱氢反应中,烯丙基取代的副反应β-H消除成为主导,从而得到α,β-不饱和化合物[3]。具体机理如下。酯基[3b],酰胺[3c],羧基[3d],氰基[3a]都能兼容,也可串联得到α,β-双官能团化产物[3e],还可与另一烯烃加成,串联得到β,γ-脱氢产物[3f]

(脱氢反应机理)

(反应底物类型)

参考文献

  1. Masha Elkin, Timothy R. Newhouse. Chem. Soc. Rev.,2018, 47, 7830–7844. DOI: 10.1039/C8CS00351C.
  2. Daria E. Kim, Joshua E. Zweig, Timothy R. Newhouse. J. Am. Chem. Soc.,2019, 141, 1479–1483. DOI: 10.1021/jacs.8b13127.
  3. a: Yifeng Chen, Justin P. Romaire, Timothy R. Newhouse,J. Am. Chem. Soc.,2015, 137, 5875. DOI: 10.1021/jacs.5b02243; b: Yifeng Chen, AnetaTurlik, Timothy R. Newhouse,J. Am. Chem. Soc., 2016,138, 1166. DOI: 10.1021/jacs.5b12924; c: Yizhou Zhao, Yifeng Chen, Timothy R. Newhouse, Angew. Chem. Int. Ed.,2017, 56, 13122-13125. DOI: 10.1002/anie.201706893; d: Yifeng Chen, David Huang†, Yizhou Zhao†, Timothy R. Newhouse, Angew. Chem. Int. Ed.,2017, 56, 8258-8262. DOI: 10.1002/anie.201704874; e: David Huang, Suzanne M. Szewczyk, Pengpeng Zhang, Timothy R. Newhouse, J. Am. Chem. Soc.,2019, 141, 5669–5674. DOI: 10.1021/jacs.9b02552.

 

  1. 本文版权属于 Chem-Station化学空间, 欢迎点击按钮分享,未经许可,谢绝转载!

Related post

  1. 卡尔·巴里·夏普莱斯 Karl Barry Sharpless
  2. 黑田千佳 (Chika Kuroda)
  3. 国武 豊喜 Toyoki Kunitake
  4. 张锋 Feng Zhang
  5. 亚瑟·霍里奇 Arthur L. Horwich
  6. 托马斯.梅耶 Thomas J. Meyer
  7. Huw M. L. Daveis
  8. 理查德 R. 施罗克 Richard R. Schrock

Comment

  1. No comments yet.

  1. No trackbacks yet.

You must be logged in to post a comment.

Pick UP!

微信

QQ

PAGE TOP