世界著名化学家

世界著名化学家 Lutz Ackermann

本文作者 alberto-caeiro

Lutz Ackermann,德国哥廷根大学(Georg-August-University Göttingen)有机化学教授,主要从事于C-H键活化及官能团化反应,曾任哥廷根大学化学系主任(2011-2015)。(图片:实验室介绍)

个人经历

  • 1993-1998, Studies of Chemistry at the Christian-Albrechts-Universität zu Kiel
  • 1997-1998, Diploma thesis (MSc) (Prof. Dr. J. Mattay)
  • 1999, Research stay at the Université de Rennes, France (Prof. Dr. P. H. Dixneuf)
  • 1998-2001, Ph.D. thesis (Mentor: Prof. Dr. A. Furstner), Max-Planck-Institut für Kohlenforschung
  • 2001-2003, Postdoctoral Studies with Prof. Dr. R. G. Bergman, UC Berkeley
  • 2003-2007, Assistant Professor, Emmy Noether-Fellow (DFG): Independent research at the LMU München (Prof. Dr. P. Knochel)
  • 2007, Chair and Full Professor (W3) at the Georg-August-University Göttingen
  • 2011-2013, Dean of the Faculty of Chemistry, Georg-August-University Göttingen
  • 2013-2015, Dean of Research, Faculty of Chemistry, Georg-August-University Göttingen
  • 2015-2017, Director of the Institute of Organic and Biomolecular Chemistry
  • 2017, PI at German Centre for Cardiovascular Research (DZHK)

获奖经历

  • 1999-2001,Kekulé-fellowship (FCI)
  • 2001-2002, Postdoctoral Scholarship (DAAD)
  • 2003-2007, Emmy Noether-Programm (DFG)
  • 2004, Thieme Journal Award
  • 2006, G.I.F. Young Scientists’ Program
  • 2006, DuPont Center for Collaborative Research & Education Grant
  • 2006, Award of the Dr. Otto-Röhm-Gedächtnisstiftung
  • 2007, Dozentenstipendium (FCI)
  • 2007, ADUC-price (GDCh)
  • 2011, Holger Erdtman Lecturer, KTH – The Royal Institute of Technology, Sweden
  • 2011, AstraZeneca Excellence in Chemistry Award
  • 2012, ERC Independent Researcher Consolidator Grant
  • 2014, Offer for a Full Proffesorship (Chair) at RWTH Aachen
  • 2014, BASF lecture, UC Berkeley
  • 2015, Thomson Reuters (Web of Science) ISI Highly Cited Researcher
  • 2015, Ta-Shue Chou Lectureship Award, Academia Sinica, Taiwan
  • 2016, Fellow of the Royal Society of Chemistry, FRSC
  • 2016, Invited Chair Professor Joliot at the École supérieure de physique et de chimie industrielles de la ville de Paris (ESPCI)
  • 2016, Molecular Science Frontier Lecture Professorship, Institute of Chemistry, Chinese Academy of Sciences (ICCAS)
  • 2017, Gottfried-Wilhelm-Leibniz-Preis
  • 2017, IOCF Yoshida Lectureship Award, Japan
  • 2017, Honorary Membership of the Israel Chemical Society
  • 2018, Visiting Professor École Polytechnique, France
  • 2018, Distinguished Visiting Professor IIT Bombay, India
  • 2018, Clarivate (Web of Science) ISI Highly Cited Researcher
  • since 2018, Associate Editor Beilstein Journal of Organic Chemistry
  • since 2018, Member of the Editorial Advisory Board of European Journal of Organic Chemistry
  • since 2013, Member of the Editorial Advisory Board of Organic Chemistry Frontiers
  • since 2009, Member of the Editorial Advisory Board of Synlett
  • since 2009, Member of the Editorial Advisory Board of Synthesis

 

工作介绍

1.C-H键官能团化(C-H BondFunctionalization)

区域选择性的C-H键活化反应常见于熵允许的分子内反应,电性控制的芳杂环化合物的官能团化反应或临近效应导致的邻位C-H键官能团化反应。而Ackermann教授利用Ru催化剂实现了远程C-H键官能团化反应[1]

除Ru催化的远程C-H键官能团化反应,Ackermann教授利用金属Ni和Mn在C-H键活化中也有应用。在2019年,作者分别发表了Ni/JoSPOphos催化的经C-H键活化分子内不对称烯烃氢芳基化反应[2a],MnCl2催化的芳杂环化合物的C-H键烷基化反应[2b]

光氧化还原催化反应(Photocatalysis)

在近些年,光氧化还原催化剂与Pd,Ru和Rh等催化剂一齐用于C-H键活化反应中。Ackermann教授将earth-abundant3d transition metals(如Cu)与光氧化还原催化剂结合的催化体系利用于C-H键官能团化反应中[3]

Flow Chemistry

Ackermann教授将Flow Chemistry的方法可很好的应用于C-H键活化体系的放大反应中[4],并且它可很好地与异相催化剂适配,从而减少反应溶剂使用量,提高催化剂的使用稳定性。

电化学(Electrochemistry)

电化学作为一种区别与热化学的反应模式,它能够为化学反应中的氧化还原试剂提供另外一种更为绿色的选择。Ackermann教授将电化学应用于C-H键官能团化反应,实现了原子经济和合成步数经济的化学合成[5]。利用此反应,Ackermann教授实现了稠环化合物的合成[5c]

 

2.配体设计与计算化学

Ackermann教授设计了一类对氧气和水稳定的secondary phosphine oxide (SPO)配体,它在杂环化合物C-H键官能团化反应中有好的立体和区域选择性控制[6]。为了更好的理解其作用机理,他们利用计算化学的方法对其催化模式进行模拟计算,量化了配体和溶剂的相互作用,并对选择性进行了预测。

3.多肽衍生化(Peptides Diversifications)

在C-H键官能团化得到极大发展的条件下,Ackermann教授利用化学反应对氨基酸和多肽进行化学修饰和衍生化,得到极具应用价值的非天然多肽和氨基酸,用于蛋白组学,药物研发等[7]

参考文献

  1. .a: For a review in C-H activation, see: P. Gandeepan, T. Müller, D. Zell, G. Cera, S. Warratz, L. Ackermann, Chem. Rev.,2019, 119, 2192.doi.org/10.1021/acs.chemrev.8b00507; b: S. R. Yetra, T. Rogge, S. Warratz, J. Struwe, W. Peng, P. Vana, L. Ackermann, Angew. Chem. Int. Ed.,2019, 58, 7490. doi.org/10.1002/anie.201901856; c: S. Warratz, D. J. Burns, C. Zhu, K. Korvorapun, T. Rogge, J. Scholz, C. Jooss, D. Gelman, L. Ackermann, Angew. Chem. Int. Ed.,2017, 56, 1557.doi.org/10.1002/anie.201609014.
  2. a: J. Loup, V. Müller, D. Ghorai, L. Ackermann, Angew. Chem. Int. Ed.,2019, 58, 1749.doi.org/10.1002/anie.201813191; b: Z. Shen, H. Huang, C. Zhu, S. Warratz, L. Ackermann, Org. Lett.,2019, 21, 571. doi.org/10.1021/acs.orglett.8b03924.
  3. a: P. Gandeepan, J. Mo, L. Ackermann, Chem. Commun.,2017, 53, 5906.DOI: 10.1039/C7CC03107F; b: F. Yang, J. Koeller, L. Ackermann, Angew. Chem. Int. Ed.2016, 55, 4759.doi.org/10.1002/anie.201512027.
  4. a: For a review, see: S. Santoro, F.Ferlin, L. Ackermann, L. Vaccaro, Chem. Soc. Rev.2019, 48, 2767.DOI: 10.1039/C8CS00211H; b: Y.-F. Liang, R. Steinbock, L. Yang, L. Ackermann, Angew. Chem. Int. Ed., 2018, 57, 10625.doi.org/10.1002/anie.201805644; c: H. Wang, F. Pesciaioli, J. C. A. Oliveira, S. Warratz, L. Ackermann, Angew. Chem. Int. Ed.2017, 56, 15063.doi.org/10.1002/anie.201708271;
  5. a: N. Sauermann, T. H. Meyer, C. Tian, L. Ackermann, J. Am. Chem. Soc., 2017, 139, 18452.doi.org/10.1021/jacs.7b11025; b: Y. Qiu, A. Scheremetjew, L. Ackermann, J. Am. Chem. Soc.2019, 141, 2731.doi.org/10.1021/jacs.8b13692;c: W.-J. Kong, L. H. Finger, J. C. A. Oliveira, L. Ackermann, Angew. Chem. Int. Ed.2019, 58, 6342.doi.org/10.1002/anie.201901565.
  6. a: J. Loup, D. Zell, J. C. A. Oliveira, H. Keil, D. Stalke, L. Ackermann, Angew. Chem. Int. Ed.2017, 56, 14197.doi.org/10.1002/anie.201709075; b: D. Zell, M. Bursch, V. Müller, S. Grimme, L. Ackermann, Angew. Chem. Int. Ed.2017, 56, 10378.doi.org/10.1002/anie.201704196.
  7. a: N. Kaplaneris, T. Rogge, R. Yin, H. Wang, G. Sirvinskaite, L. Ackermann, Angew. Chem. Int. Ed.2019, 58, 3476.doi.org/10.1002/ange.201812705; b: M Bauer, W. Wang, M. M. Lorion, C. Dong, L. Ackermann, Angew. Chem. Int. Ed.2017, 56, 203. doi.org/10.1002/anie.201710136; c: Z. Ruan, N. Sauermann, E. Manoni, L. Ackermann, Angew. Chem. Int. Ed.2017, 56, 3172.doi.org/10.1002/anie.201611118; d: A. Schischko, H. Ren, N. Kaplaneris, L. Ackermann, Angew. Chem. Int. Ed., 2017, 56, 1576.doi.org/10.1002/anie.201609631.

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