世界著名化学家 Lutz Ackermann

世界著名化学家

世界著名化学家 Lutz Ackermann

2019/6/22
世界著名化学家
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Author: Peng Li

本文作者 alberto-caeiro

Lutz Ackermann，德国哥廷根大学(Georg-August-University Göttingen)有机化学教授，主要从事于C-H键活化及官能团化反应，曾任哥廷根大学化学系主任(2011-2015)。(图片：实验室介绍)

个人经历

1993-1998, Studies of Chemistry at the Christian-Albrechts-Universität zu Kiel
1997-1998, Diploma thesis (MSc) (Prof. Dr. J. Mattay)
1999, Research stay at the Université de Rennes, France (Prof. Dr. P. H. Dixneuf)
1998-2001, Ph.D. thesis (Mentor: Prof. Dr. A. Furstner), Max-Planck-Institut für Kohlenforschung
2001-2003, Postdoctoral Studies with Prof. Dr. R. G. Bergman, UC Berkeley
2003-2007, Assistant Professor, Emmy Noether-Fellow (DFG): Independent research at the LMU München (Prof. Dr. P. Knochel)
2007, Chair and Full Professor (W3) at the Georg-August-University Göttingen
2011-2013, Dean of the Faculty of Chemistry, Georg-August-University Göttingen
2013-2015, Dean of Research, Faculty of Chemistry, Georg-August-University Göttingen
2015-2017, Director of the Institute of Organic and Biomolecular Chemistry
2017, PI at German Centre for Cardiovascular Research (DZHK)

获奖经历

1999-2001,Kekulé-fellowship (FCI)
2001-2002, Postdoctoral Scholarship (DAAD)
2003-2007, Emmy Noether-Programm (DFG)
2004, Thieme Journal Award
2006, G.I.F. Young Scientists’ Program
2006, DuPont Center for Collaborative Research & Education Grant
2006, Award of the Dr. Otto-Röhm-Gedächtnisstiftung
2007, Dozentenstipendium (FCI)
2007, ADUC-price (GDCh)
2011, Holger Erdtman Lecturer, KTH – The Royal Institute of Technology, Sweden
2011, AstraZeneca Excellence in Chemistry Award
2012, ERC Independent Researcher Consolidator Grant
2014, Offer for a Full Proffesorship (Chair) at RWTH Aachen
2014, BASF lecture, UC Berkeley
2015, Thomson Reuters (Web of Science) ISI Highly Cited Researcher
2015, Ta-Shue Chou Lectureship Award, Academia Sinica, Taiwan
2016, Fellow of the Royal Society of Chemistry, FRSC
2016, Invited Chair Professor Joliot at the École supérieure de physique et de chimie industrielles de la ville de Paris (ESPCI)
2016, Molecular Science Frontier Lecture Professorship, Institute of Chemistry, Chinese Academy of Sciences (ICCAS)
2017, Gottfried-Wilhelm-Leibniz-Preis
2017, IOCF Yoshida Lectureship Award, Japan
2017, Honorary Membership of the Israel Chemical Society
2018, Visiting Professor École Polytechnique, France
2018, Distinguished Visiting Professor IIT Bombay, India
2018, Clarivate (Web of Science) ISI Highly Cited Researcher
since 2018, Associate Editor Beilstein Journal of Organic Chemistry
since 2018, Member of the Editorial Advisory Board of European Journal of Organic Chemistry
since 2013, Member of the Editorial Advisory Board of Organic Chemistry Frontiers
since 2009, Member of the Editorial Advisory Board of Synlett
since 2009, Member of the Editorial Advisory Board of Synthesis

工作介绍

1.C-H键官能团化(C-H BondFunctionalization)

区域选择性的C-H键活化反应常见于熵允许的分子内反应，电性控制的芳杂环化合物的官能团化反应或临近效应导致的邻位C-H键官能团化反应。而Ackermann教授利用Ru催化剂实现了远程C-H键官能团化反应^[1]。

除Ru催化的远程C-H键官能团化反应，Ackermann教授利用金属Ni和Mn在C-H键活化中也有应用。在2019年，作者分别发表了Ni/JoSPOphos催化的经C-H键活化分子内不对称烯烃氢芳基化反应^[2a]，MnCl₂催化的芳杂环化合物的C-H键烷基化反应^[2b]。

光氧化还原催化反应(Photocatalysis)

在近些年，光氧化还原催化剂与Pd，Ru和Rh等催化剂一齐用于C-H键活化反应中。Ackermann教授将earth-abundant3d transition metals（如Cu）与光氧化还原催化剂结合的催化体系利用于C-H键官能团化反应中^[3]。

Flow Chemistry

Ackermann教授将Flow Chemistry的方法可很好的应用于C-H键活化体系的放大反应中^[4]，并且它可很好地与异相催化剂适配，从而减少反应溶剂使用量，提高催化剂的使用稳定性。

电化学(Electrochemistry)

电化学作为一种区别与热化学的反应模式，它能够为化学反应中的氧化还原试剂提供另外一种更为绿色的选择。Ackermann教授将电化学应用于C-H键官能团化反应，实现了原子经济和合成步数经济的化学合成^[5]。利用此反应，Ackermann教授实现了稠环化合物的合成^[5c]。

2.配体设计与计算化学

Ackermann教授设计了一类对氧气和水稳定的secondary phosphine oxide (SPO)配体，它在杂环化合物C-H键官能团化反应中有好的立体和区域选择性控制^[6]。为了更好的理解其作用机理，他们利用计算化学的方法对其催化模式进行模拟计算，量化了配体和溶剂的相互作用，并对选择性进行了预测。

3.多肽衍生化(Peptides Diversifications)

在C-H键官能团化得到极大发展的条件下，Ackermann教授利用化学反应对氨基酸和多肽进行化学修饰和衍生化，得到极具应用价值的非天然多肽和氨基酸，用于蛋白组学，药物研发等^[7]。

参考文献

.a: For a review in C-H activation, see: P. Gandeepan, T. Müller, D. Zell, G. Cera, S. Warratz, L. Ackermann, Chem. Rev.,2019, 119, 2192.doi.org/10.1021/acs.chemrev.8b00507; b: S. R. Yetra, T. Rogge, S. Warratz, J. Struwe, W. Peng, P. Vana, L. Ackermann, Angew. Chem. Int. Ed.,2019, 58, 7490. doi.org/10.1002/anie.201901856; c: S. Warratz, D. J. Burns, C. Zhu, K. Korvorapun, T. Rogge, J. Scholz, C. Jooss, D. Gelman, L. Ackermann, Angew. Chem. Int. Ed.,2017, 56, 1557.doi.org/10.1002/anie.201609014.
a: J. Loup, V. Müller, D. Ghorai, L. Ackermann, Angew. Chem. Int. Ed.,2019, 58, 1749.doi.org/10.1002/anie.201813191; b: Z. Shen, H. Huang, C. Zhu, S. Warratz, L. Ackermann, Org. Lett.,2019, 21, 571. doi.org/10.1021/acs.orglett.8b03924.
a: P. Gandeepan, J. Mo, L. Ackermann, Chem. Commun.,2017, 53, 5906.DOI: 10.1039/C7CC03107F; b: F. Yang, J. Koeller, L. Ackermann, Angew. Chem. Int. Ed., 2016, 55, 4759.doi.org/10.1002/anie.201512027.
a: For a review, see: S. Santoro, F.Ferlin, L. Ackermann, L. Vaccaro, Chem. Soc. Rev., 2019, 48, 2767.DOI: 10.1039/C8CS00211H; b: Y.-F. Liang, R. Steinbock, L. Yang, L. Ackermann, Angew. Chem. Int. Ed., 2018, 57, 10625.doi.org/10.1002/anie.201805644; c: H. Wang, F. Pesciaioli, J. C. A. Oliveira, S. Warratz, L. Ackermann, Angew. Chem. Int. Ed., 2017, 56, 15063.doi.org/10.1002/anie.201708271;
a: N. Sauermann, T. H. Meyer, C. Tian, L. Ackermann, J. Am. Chem. Soc., 2017, 139, 18452.doi.org/10.1021/jacs.7b11025; b: Y. Qiu, A. Scheremetjew, L. Ackermann, J. Am. Chem. Soc., 2019, 141, 2731.doi.org/10.1021/jacs.8b13692;c: W.-J. Kong, L. H. Finger, J. C. A. Oliveira, L. Ackermann, Angew. Chem. Int. Ed., 2019, 58, 6342.doi.org/10.1002/anie.201901565.
a: J. Loup, D. Zell, J. C. A. Oliveira, H. Keil, D. Stalke, L. Ackermann, Angew. Chem. Int. Ed., 2017, 56, 14197.doi.org/10.1002/anie.201709075; b: D. Zell, M. Bursch, V. Müller, S. Grimme, L. Ackermann, Angew. Chem. Int. Ed., 2017, 56, 10378.doi.org/10.1002/anie.201704196.
a: N. Kaplaneris, T. Rogge, R. Yin, H. Wang, G. Sirvinskaite, L. Ackermann, Angew. Chem. Int. Ed., 2019, 58, 3476.doi.org/10.1002/ange.201812705; b: M Bauer, W. Wang, M. M. Lorion, C. Dong, L. Ackermann, Angew. Chem. Int. Ed., 2017, 56, 203. doi.org/10.1002/anie.201710136; c: Z. Ruan, N. Sauermann, E. Manoni, L. Ackermann, Angew. Chem. Int. Ed., 2017, 56, 3172.doi.org/10.1002/anie.201611118; d: A. Schischko, H. Ren, N. Kaplaneris, L. Ackermann, Angew. Chem. Int. Ed., 2017, 56, 1576.doi.org/10.1002/anie.201609631.