世界著名化学家

Erick M. Carreira

Erick M. Carreira教授1963年生于哈瓦那、古巴(Havana Cuba)。现为苏黎世联邦理工学院有机化学教授,ACS旗下杂志Organic Letter主编。(图片来自:Org Lett)

 

经历

  • 1984年 University of Illinois at Urbana-Champaign, B.S. Scott E. Denmark;
  • 1990年 Harvard University, Ph.D. David A. Evans;
  • 1992年 California Institute of Technology, Postdoctoral,Peter Dervan;
  • 1996年California Institute of Technology,助理教授
  • 1997年California Institute of Technology, 教授
  • 1998年-现在Swiss Federal Institute of Technology Zurich, 教授

 

获奖经历

  • American Chemical Society Award in Pure Chemistry;
  • Nobel Laureate Signature Award;
  • Fresenius Award;
  • David and Lucile Packard Foundation Fellowship in Science;
  • Alfred P. Sloan Fellowship;
  • Camille and Henry Dreyfus Teacher Scholar Award;
  • Merck Young Investigator Award;
  • Eli Lilly Young Investigator Award;
  • Pfizer Research Award, National Science Foundation CAREER Award;
  • Arnold and Mabel Beckman Young Investigator Award;
  • Camille and Henry Dreyfus New Faculty Award;
  • the Associated Students of the California Institute of Technology Annual Award in Teaching;
  • Richard M. Badger Award in Teaching;

 

研究概览

1.生物活性分子的全合成

Erick M. Carreira教授一直致力于有生物活性和结构复杂的天然产物分子高效全合成,课题组至今已合成许多天然产物,图一为代表性分子的合成。其中,Chlorosulpholipid Cytotoxin的合成工作发表于顶级期刊Nature【1】

图1:Representative Synthesis

 

2.合成策略的开发

Erick M. Carreira教授的合成方法学主要包括一下方面:联烯不对称烷基化反应{2}(图2a),不对称的烯丙基取代反应及其机理研究[3,4](图2b, c),对映选择性和非对映选择性的双催化剂在手性合成中的应用[5](图2d),非活化双键的氢氯化反应[6](图2e),环丙烷和环丙烯的不对称三氟甲基化反应[7](图2f),水相中的不对称转移氢化反应[8](图2g)。

a: Iridium-Catalyzed Enantioconvergent Allenylic Alkylation

b: Iridium-Catalyzed Enantioconvergent Allylic Substitution

c: Mechanistic Studies Regarding the Iridium Catalyzed Enantioselective Allylic Substitution

d: Enantio- and Diastereodivergent Dual Catalysis and Its Application

e: Trifluoromethylation of Cyclopropanes & Cyclopropenes

f: Hydrochlorination of Unactivated Olefins

g: Asymmetric Transfer Hydrogenations in Water

图2:Representative Catalytic Methods

  1. 药物化学

Erick. M. Carreira教授在药物活性片段及活性方面也有许多研究,活性分子的氟化,杂环SF5­­­­化反应(图3a),螺环胺(图3b),氧杂环丁烷(图3c)。

a: 杂环SF5­­­­化反应

b:螺环胺合成

c:氧杂环丁烷合成

图3:Representative Workin Medicinal Chemistry

 

参考文献

1.C. Nilewski, R.W. Geisser, E. M. Carreira, Nature 2009, 547, 573.doi.org/10.1038/nature07734.

  1. D.A. Petrone, M. Isomura, I. Franzoni, S.L. Rössler, E.M. Carreira, J. Am. Chem. Soc. 2018, 140,4697. DOI: 10.1021/jacs.8b01416.
  2. J. Y. Hamilton, D. Sarlah, E. M. Carreira, J. Am. Chem. Soc. 2014, 136, 3006. DOI: 10.1021/ja412962w.
  3. S.L. Rössler, S.Krautwald, E.M. Carreira, J. Am. Chem. Soc. 2017, 139, 3603-3606.DOI: 10.1021/jacs.6b12421.
  4. a: S. Krautwald, D. Sarlah, M. A. Schafroth, E. M. Carreira, Science, 2013, 340, 1065.DOI: 10.1126/science.1237068; b: (Perspective) S. Krautwald, E.M. Carreira, J. Am. Chem. Soc. 2017, 139, 5627-5639. DOI: 10.1021/jacs.6b13340.
  5. a: B. Morandi, E. M. Carreira, Angew. Chem. Int. Ed. 2010, 49, 938. doi.org/10.1002/anie.200905573;b: B. Morandi, E. M. Carreira, Angew. Chem. Int. Ed. 2010, 49, 4294.doi.org/10.1002/anie.201000787;
  6. B. Gaspar, E. M. Carreira, Angew. Chem. Int. Ed. 2008, 47, 5758. doi.org/10.1002/anie.200801760.
  7. O. Soltani, M. A. Ariger, H. Vázquez-Villa, E. M. Carreira, Org. Lett. 2010, 12, 2893. DOI: 10.1021/ol1008894.

 

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