世界著名化学家

David A. Evans

本文投稿作者 alberto-caeiro

David A. Evans,美国有机化学家,现为哈佛大学教授。现代有机全合成界泰斗级人物,许多合成化学家出自其门下。(照片:实验室主页

 

经历

  • 1963 奥伯林大学(Oberlin College)B. S.;
  • 1967 加州理工学院(California Institute of Technology)Ph. D.;
  • 1967-1972 加州大学洛杉矶分校 助教;
  • 1972-1974 加州大学洛杉矶分校 副教授
  • 1974 加州大学洛杉矶分校 教授
  • 1974-1983 加州理工学院 教授
  • 1983-1990 哈佛大学 教授
  • 1990-2008 哈佛大学名誉教授(Abbott and James Lawrence Professor of Chemistry)
  • 1995-1998 哈佛大学化学系主任

 

获奖经历

  • 1971 Camille and Henry Dreyfus Teacher-Scholar Award
  • 1972 Alfred P. Sloan Foundation Fellow
  • 1973 Distinguished Teaching Award, UCLA Alumni Association
  • 1982 ACS Award for Creative Work in Synthetic Organic Chemistry
  • 1983 M.A., Honorary, Harvard University, Cambridge, MA
  • 1984 Allen R. Day Award, Philadelphia Organic Chemists Club, Philadelphia, PA
  • 1984 Elected to National Academy of Sciences
  • 1988 Arthur C. Cope Scholar Award, American Chemical Society
  • 1988 American Academy of Arts and Sciences
  • 1992 C. S. Hamilton Award, University of Nebraska
  • 1992 Mack Award, Ohio State University
  • 1992 Fellow, American Association for the Advancement of Science
  • 1992 Pfizer Research Award for Synthetic Organic Chemistry, Pfizer, Inc.
  • 1996 Remsen Award, Maryland Section, American Chemical Society
  • 1997 Yamada Prize, University of Tokyo, Japan
  • 1998 Tetrahedron Prize
  • 1998 Robert Robinson Award from the Royal Society of Chemistry, UK
  • 1999 The Prelog Medal, ETH, Zurich Switzerland
  • 2000 Arthur C. Cope Award, American Chemical Society
  • 2001 Elected to The Royal Society of Chemistry
  • 2002 California Institute of Technology, Distinguished Alumni Award
  • 2003 The Nagoya Medal, Nagoya University, Japan
  • 2003 Karl Ziegler Prize, Max Planck, Muelheim, Germany
  • 2005 Willard Gibbs Medal, Chicago Section of the American Chemical Society
  • 2006 Ryoji Noyori Prize, Society of Synthetic Organic Chemistry, Japan
  • 2006 Thomson Scientific Laureate in Chemistry, Thomson Scientific
  • 2006 Glenn T. Seaborg Medal, awarded by the University of California, Los Angeles
  • 2007 Herbert C. Brown Award for Creative Research in Synthetic Methods, sponsored by the American Chemical Society
  • 2007 Phi Beta Kappa Teaching Prize for Contributions to Undergraduate Education 2008      Elected Fellow of the Royal Society of Chemistry, UK
  • 2008 Humboldt Research Award for Senior Scientists, the Alexander von Humboldt Foundation
  • 2008 Elected Fellow of the Royal Society of Chemistry, UK
  • 2010 ACS Award for Creativity in Molecular Design and Synthesis
  • 2012 Welch Prize in Chemistry, awarded by the Welch Foundation
  • 2013 Roger Adams Award

 

研究概要

新型反应的开发及复杂天然产物的全合成

Evans教授最有名的人名反应当属Evans-Aldol Reaction[1](mechanismfrom Strategic Applicationsof Named Reactions inOrganic Synthesis),图1。通过使用从氨基酸得到的手性噁唑烷酮辅基,可以得到顺式的aldol产物。这种条件下的aldol反应可靠性高,可以运用到大量反应中,并且立体化学容易预测,因此,在许多复杂天然产物的合成中都有良好的运用。Evans-Aldol反应和不对称烯丙基硼化反应一起,在链式化合物的合成与立体结构的控制中,仍然被经常使用着。

图1:Evans-Aldol Reaction

通过自己组开发的方法学,David A. Evans教授完成了许多复杂天然产物的全合成,下图仅为部分全合成工作。

图2:David A. Evans部分全合成工作

 

评论&其他

  • David A. Evans教授是美国有机合成界当之无愧的大牛之一,培养了许多优秀的有机化学家,在美国的有机合成化学领域大多数化学家就有属于分属Corey派和Evans派之说。
  • David A. Evans教授还是现今有机化学中使用最为广泛的软件——ChemDraw的开发者之一[2]

 

相关文献

  1. (a) Evans, D. A.; Vogel, E.; Nelson, J. V. J. Am. Chem. Soc. 1979, 101, 6120. DOI:10.1021/ja00514a045.; (b) Evans, D. A.; Bartroli, J.; Shih, T. L. J. Am. Chem. Soc. 1981, 103, 2127. DOI: 10.1021/ja00398a058.; (c) Evans, D. A. Aldrichimica Acta 1982, 15, 23.; (d) Recent Review: Heravi, M. M.; Zadsirjan, V. Tetrahedron: Asymmetry 2013, 24, 1149.;
  2. Evans, D. A. Angew. Chem. Int. Ed. 2014, 53, 11140. DOI: 10.1002/anie.201405820

 

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