世界著名化学家

Nicholas Turner

Nicholas Turner, 1960年6月2日英国、肯特州Orpington出生,是英国著名的酶化学家。曼彻斯特大学教授(照片:曼彻斯特大学化学系)。

履历

  • 1979‐1982 University of Bristol, Chemistry (BSc)
  • 1982‐1985 University of Oxford, 博士学位 (Prof. J. E. Baldwin)
  • 1985‐1987 Royal Society Junior Research Fellow
  • 1985/86 Oxford University, (Dyson Perrins Laboratory)
  • 1986/87 Harvard, Department of Chemistry, (Prof. G. M. Whitesides)
  • 1987‐1995 University of Exeter, Department of Chemistry, 讲师
  • 1995‐1998 University of Edinburgh, Reader in Bio‐Organic Chemistry
  • 1998‐2004 University of Edinburgh, Chemical Biology, 教授
  • 2003 Co‐founder and Chief Scientific Officer of Ingenza Ltd
  • 2004- University of Manchester, chemical biology, 教授
  • 2005 ‐ Director of Centre of Excellence in Biocatalysis, Biotransformation and Biocatalytic Manufacturing (CoEBio3)
  • 2012 Co‐founder and Director of Discovery Biocatalysts

顾问兼任: AstraZeneca (UK), Johnson Matthey (UK), Lonza (Switzerland), Evolva (Switzerland), Bactevo (UK), Asymchem (China), Dr. Reddy’s Research Laboratories 其他还兼任多个Advisory Board

获奖经历

  • 1992 RSC Medal for Carbohydrate Chemistry
  • 1995 Pfizer Academic Award for Organic Chemistry
  • 1996 RSC Corday‐Morgan Medal and Prize
  • 2004 Biocat Award
  • 2007 AZ/GSK/Pfizer UK Prize for Process Chemistry Research
  • 2009 Royal Society of Chemistry Industrial Organic Award
  • 2011 Royal Society Wolfson Research Merit Award
  • 2017 ERC Advanced Grant Fellowship 2017-2022
  • 2017 RSC Organic Stereochemistry Award
  • 2018 ACS Catalysis Award

研究业绩

胺在天然产物,API,Bulk chemical等多种地方出现的官能团、因此在合成化学中,胺的合成也显得尤为重要。Turner因为monoamine oxidase (MAO)[1]与最近imine reductase (IRED)[2]reductive aminase [3]胺合成酶的开发而闻名。由于能够高对映选择性地合成未保护的手性胺,这些酶的开发吸引了业界的广泛关注。

此外,除了活用wild type的酶之外,他也通过使用Directed Evolution对酶进行修饰,以达到扩大底物适用范围以及实现工业生产[4]。

同时、也在进行运用Biocatalyst进行天然产物与医药品的合成的研究[5]。

其他

  • 他的妻子Sabine L. Flitsch也在同一个研究所,主宰这另一个研究室。夫妻俩也在进行着合作研究。

相关视频

相关文献

[1] Köhler, V.; Bailey, K. R.; Znabet, A.; Raftery, J.; Helliwell, M.; Turner, N. J. Angew. Chem. Int. Ed. 2010, 49 (12), 2182.DOI: 10.1002/anie.200906655.[2] Grogan, G.; Turner, N. J. Chem. A Eur. J. 2016, 22 (6), 1900. DOI: 10.1002/chem.201503954.[3] Aleku, G. A.; France, S. P.; Man, H.; Mangas-Sanchez, J.; Montgomery, S. L.; Sharma, M.; Leipold, F.; Hussain, S.; Grogan, G.; Turner, N. J. Nat. Chem. 2017, 9(10), 961. DOI: 10.1038/nchem.2782.[4] Turner, N. J. Nat. Chem. Biol. 2009, 5 (8), 567.DOI: 10.1038/nchembio.203.[5] Turner, N. J.; O’Reilly, E. Nat. Chem. Biol. 2013, 9 (5), 285. DOI:10.1038/nchembio.1235.; Green, A. P.; Turner, N. J. Perspect. Sci. 2016, 9, 42.DOI: 10.1016/j.pisc.2016.04.106.; Hönig, M.; Sondermann, P.; Turner, N. J.; Carreira, E. M. Angew. Chem. Int. Ed. 2017, 56 (31), 8942. DOI:10.1002/anie.201612462.

相关书籍(日亚价格)

Biocatalysis in Organic Synthesis: The Retrosynthesis Approach (English Edition)

Biocatalysis in Organic Synthesis: The Retrosynthesis Approach (English Edition)

  • 作者Nicholas J Turner,Luke Humphreys
  • 出版日2018/02/15
  • Kindle版429页
  • 出版社Royal Society of Chemistry
Introduction to Biocatalysis Using Enzymes and Microorganisms

Introduction to Biocatalysis Using Enzymes and Microorganisms

  • 作者S. M. Roberts,Nicholas J. Turner,Andrew J. Willetts,Michael K. Turner
  • 参考价¥ 5,294
    价格¥ 5,268(2019/03/22 21:58時点)
  • 出版日1995/01/27
  • 页码 208页
  • ISBN-100521436850
  • ISBN-139780521436854
  • 出版社Cambridge University Press

相关链接

本文版权属于 Chem-Station化学空间 欢迎点击按钮分享,未经许可,谢绝转载!

Related post

  1. 格雷格·保罗·温特 Gregory Paul Winter
  2. 卡洛琳・贝尔托齐 Carolyne R. Bertozzi
  3. 浜地 格 Itaru Hamachi
  4. Burkhard König
  5. W. Clark. Still
  6. Daniel Singleton
  7. Andrei K. Yudin
  8. 安达 千波矢 Chihaya Adachi

Comment

  1. No comments yet.

  1. No trackbacks yet.

You must be logged in to post a comment.

Pick UP!

微信

QQ

PAGE TOP