世界著名化学家

Nicholas Turner

Nicholas Turner, 1960年6月2日英国、肯特州Orpington出生,是英国著名的酶化学家。曼彻斯特大学教授(照片:曼彻斯特大学化学系)。

履历

  • 1979‐1982 University of Bristol, Chemistry (BSc)
  • 1982‐1985 University of Oxford, 博士学位 (Prof. J. E. Baldwin)
  • 1985‐1987 Royal Society Junior Research Fellow
  • 1985/86 Oxford University, (Dyson Perrins Laboratory)
  • 1986/87 Harvard, Department of Chemistry, (Prof. G. M. Whitesides)
  • 1987‐1995 University of Exeter, Department of Chemistry, 讲师
  • 1995‐1998 University of Edinburgh, Reader in Bio‐Organic Chemistry
  • 1998‐2004 University of Edinburgh, Chemical Biology, 教授
  • 2003 Co‐founder and Chief Scientific Officer of Ingenza Ltd
  • 2004- University of Manchester, chemical biology, 教授
  • 2005 ‐ Director of Centre of Excellence in Biocatalysis, Biotransformation and Biocatalytic Manufacturing (CoEBio3)
  • 2012 Co‐founder and Director of Discovery Biocatalysts

顾问兼任: AstraZeneca (UK), Johnson Matthey (UK), Lonza (Switzerland), Evolva (Switzerland), Bactevo (UK), Asymchem (China), Dr. Reddy’s Research Laboratories 其他还兼任多个Advisory Board

获奖经历

  • 1992 RSC Medal for Carbohydrate Chemistry
  • 1995 Pfizer Academic Award for Organic Chemistry
  • 1996 RSC Corday‐Morgan Medal and Prize
  • 2004 Biocat Award
  • 2007 AZ/GSK/Pfizer UK Prize for Process Chemistry Research
  • 2009 Royal Society of Chemistry Industrial Organic Award
  • 2011 Royal Society Wolfson Research Merit Award
  • 2017 ERC Advanced Grant Fellowship 2017-2022
  • 2017 RSC Organic Stereochemistry Award
  • 2018 ACS Catalysis Award

研究业绩

胺在天然产物,API,Bulk chemical等多种地方出现的官能团、因此在合成化学中,胺的合成也显得尤为重要。Turner因为monoamine oxidase (MAO)[1]与最近imine reductase (IRED)[2]reductive aminase [3]胺合成酶的开发而闻名。由于能够高对映选择性地合成未保护的手性胺,这些酶的开发吸引了业界的广泛关注。

此外,除了活用wild type的酶之外,他也通过使用Directed Evolution对酶进行修饰,以达到扩大底物适用范围以及实现工业生产[4]。

同时、也在进行运用Biocatalyst进行天然产物与医药品的合成的研究[5]。

其他

  • 他的妻子Sabine L. Flitsch也在同一个研究所,主宰这另一个研究室。夫妻俩也在进行着合作研究。

相关视频

相关文献

[1] Köhler, V.; Bailey, K. R.; Znabet, A.; Raftery, J.; Helliwell, M.; Turner, N. J. Angew. Chem. Int. Ed. 2010, 49 (12), 2182.DOI: 10.1002/anie.200906655.[2] Grogan, G.; Turner, N. J. Chem. A Eur. J. 2016, 22 (6), 1900. DOI: 10.1002/chem.201503954.[3] Aleku, G. A.; France, S. P.; Man, H.; Mangas-Sanchez, J.; Montgomery, S. L.; Sharma, M.; Leipold, F.; Hussain, S.; Grogan, G.; Turner, N. J. Nat. Chem. 2017, 9(10), 961. DOI: 10.1038/nchem.2782.[4] Turner, N. J. Nat. Chem. Biol. 2009, 5 (8), 567.DOI: 10.1038/nchembio.203.[5] Turner, N. J.; O’Reilly, E. Nat. Chem. Biol. 2013, 9 (5), 285. DOI:10.1038/nchembio.1235.; Green, A. P.; Turner, N. J. Perspect. Sci. 2016, 9, 42.DOI: 10.1016/j.pisc.2016.04.106.; Hönig, M.; Sondermann, P.; Turner, N. J.; Carreira, E. M. Angew. Chem. Int. Ed. 2017, 56 (31), 8942. DOI:10.1002/anie.201612462.

相关书籍(日亚价格)

Biocatalysis in Organic Synthesis: The Retrosynthesis Approach (English Edition)

Biocatalysis in Organic Synthesis: The Retrosynthesis Approach (English Edition)

  • 作者Nicholas J Turner,Luke Humphreys
  • 出版日2018/02/15
  • Kindle版429页
  • 出版社Royal Society of Chemistry
Introduction to Biocatalysis Using Enzymes and Microorganisms

Introduction to Biocatalysis Using Enzymes and Microorganisms

  • 作者S. M. Roberts,Nicholas J. Turner,Andrew J. Willetts,Michael K. Turner
  • 参考价¥ 5,294
    价格¥ 5,268(2019/03/22 21:58時点)
  • 出版日1995/01/27
  • 页码 208页
  • ISBN-100521436850
  • ISBN-139780521436854
  • 出版社Cambridge University Press

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